2′-Hydroxychalcone

2′-Hydroxychalcone is a hydroxyl derivative of chalcones with anticancer activities. 2'-Hydroxychalcone inhibits NF-κB pathway and induces autophagy and apoptosis in breast cancer cells[1]. 2′-Hydroxychalcone shows a better antifungal activity against the complex Paracoccidioides spp[2].

Product Specifications

CAS Number

[1214-47-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Fungal; NF-κB

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/2-hydroxychalcone-1.html

Purity

97.45

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(C1=C(O)C=CC=C1)/C=C/C2=CC=CC=C2

Molecular Formula

C15H12O2

Molecular Weight

224.26

Precautions

H302, H315, H319, H335

References & Citations

[1]Kaila P Medina-Alarcón, et al. Antifungal activity of 2'-hydroxychalcone loaded in nanoemulsion against Paracoccidioides spp. Future Microbiol. 2020 Jan:15:21-33. |[2]Xiao Wang, et al. 2'-Hydroxychalcone Induces Autophagy and Apoptosis in Breast Cancer Cells via the Inhibition of the NF-κB Signaling Pathway: In Vitro and In Vivo Studies. Nutrients. 2024 Feb 13;16 (4) :514.