NC 2300

NC 2300 (VEL-0230) is a selective and orally active cysteine cathepsin inhibitor with the IC50 values of 284, 34.5, and 186 nM for cathepsin B, K, and S, respectively.NC 2300 can be used for study of diseases involving bone mineral disorders[1][2].

Product Specifications

CAS Number

[221144-20-3]

Product Name Alternative

VEL 0230

UNSPSC

12352005

Target

Cathepsin

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nc-2300.html

Smiles

CC(C)COC[C@H](CC(C)C)NC([C@@H]1[C@H](O1)C(O[Na])=O)=O

Molecular Formula

C14H24NNaO5

Molecular Weight

309.33

References & Citations

[1]Aoki T, et al. Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms. Stroke. 2008;39 (9) :2603-2610.|[2]Hirai T, et al. Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation [published correction appears in J Immunol. 2014 May 15;192 (10) :4933]. J Immunol. 2013;190 (9) :4805-4811.