AM4299B
AM4299B is an inhibitor for thiol protease. AM4299B inhibits bovine spleen cathepsin B, human kidney cathepsin L and papain with IC50s of 0.7, 0.5 and 20 μM, respectively. AM4299B can be used in research in osteoporosis, and has potential to be used as an antiparasitic agent[1].
Product Specifications
CAS Number
[160825-49-0]
UNSPSC
12352211
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/am4299b.html
Smiles
N[C@@H](CCCCNC([C@H](CC(C)C)NC(C1OC1C(O)=O)=O)=O)C(O)=O
Molecular Formula
C16H27N3O7
Molecular Weight
373.40
References & Citations
[1]Morishita A, et al., AM4299 A and B, novel thiol protease inhibitors. J Antibiot (Tokyo) . 1994 Sep;47 (9) :1065-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cathepsin B; Cathepsin L
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