MLK-IN-2
Product Specifications
UNSPSC Description
MLK-IN-2 (Compound 9a) is a Mixed Lineage Kinase 3 (MLK3) inhibitor containing 3H-imidazole [4,5-b] pyridine structure. IC50 value is 6 nM. MLK-IN-2 can be used to study cancer and neurodegenerative diseases[1].
Target Antigen
Mixed Lineage Kinase
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/mlk-in-2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CCOCC1)C2=CC=CC(N3C(C)=C(C4=NC(C(N[C@H]5CCN(S(CC)(=O)=O)C5)=C(Br)C=N6)=C6N4)C=C3C)=C2
Molecular Weight
656.59
References & Citations
[1]Yoon HR, et al. Design, synthesis of new 3H-imidazo[4,5-b]pyridine derivatives and evaluation of their inhibitory properties as mixed lineage kinase 3 inhibitors. Bioorg Med Chem Lett. 2024 Feb 10;101:129652.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161271/MLK-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161271/
Clinical Information
No Development Reported
CAS Number
2614255-51-3
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