Defensin HNP-1 human
Product Specifications
UNSPSC Description
Defensin HNP-1 human is a Human neutrophil peptides (HNPs), involved in endothelial cell dysfunction at the time of early atherosclerotic development. Defensin HNP-1 human exhibits broad antimicrobial and anti-leishmanial activities[1][2].
Target Antigen
Bacterial; Parasite
Type
Peptides
Related Pathways
Anti-infection
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/defensin-hnp-1-human.html
Solubility
H2O
Smiles
O=C([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@](NC([C@@]1([H])NC([C@](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@](NC([C@]2([H])CSSC[C@](C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@](CSSC1)([H])C(N[C@H](C(N[C@@](C(N3[C@](CCC3)([H])C(N[C@H](C(N2)=O)C)=O)=O)([H])[C@@H](C)CC)=O)CCCNC(N)=N)=O)=O)CC4=CC=C(C=C4)O)=O)NC([C@@H](N)C)=O)C(O)=O)=O)([H])NC([C@@H](NC([C@@H](NC5=O)C)=O)CC6=CC=CC=C6)=O)=O)([H])[C@@H](C)CC)=O)C)=O)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC7=CC=C(C=C7)O)=O)=O)([H])[C@H](O)C)=O)=O)([H])[C@@H](C)CC)=O)CC8=CC=C(C=C8)O)=O)CCC(N)=O)=O)=O)CCCNC(N)=N)=O)CC(C)C)N[C@H]5CC9=CNC%10=CC=CC=C9%10
Molecular Weight
3442.03
References & Citations
[1]Dabirian S, et, al. Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate. PLoS Negl Trop Dis. 2013 Oct 17;7(10):e2491.|[2]Higazi M, et, al. Opposing effects of HNP1 (α-defensin-1) on plasma cholesterol and atherogenesis. PLoS One. 2020 Apr 17;15(4):e0231582.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P2310/Defensin-HNP-1-human-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P2310/
Clinical Information
No Development Reported
CAS Number
148093-65-6
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