Omecamtiv mecarbil-d8
Product Specifications
UNSPSC Description
Omecamtiv mecarbil-d8 is the deuterium labeled Omecamtiv mecarbil. Omecamtiv mecarbil (CK-1827452) is a selective cardiac myosin activator.
Target Antigen
Isotope-Labeled Compounds; Myosin
Type
Isotope-Labeled Compounds
Related Pathways
Cytoskeleton;Others
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
O=C(N1C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C1([2H])[2H])CC2=C(C(NC(NC3=CC=C(N=C3)C)=O)=CC=C2)F)OC
Molecular Weight
409.48
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Morgan BP, et al. Discovery of omecamtiv mecarbil the first, selective, small molecule activator of cardiac Myosin. ACS Med Chem Lett. 2010 Aug 20;1(9):472-7.|[3]Mamidi R, et al. Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C. J Mol Cell Cardiol. 2015 Aug;85:262-72.|[4]Swenson AM, et al. Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle. J Biol Chem. 2017 Mar 3;292(9):3768-3778.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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