Dexfadrostat
Dexfadrostat ((R) -Fadrozole) is a potent nonsteroidal inhibitor[1]. Dexfadrostat also inhibits human placental aromatase (pIC50 = 6.17) and aldosterone biosynthesis. Dexfadrostat reverses cardiac fibrosis in spontaneously hypertensive heart failure rats.[1][2].
Product Specifications
CAS Number
[102676-87-9]
Product Name Alternative
(R) -Fadrozole; (R) -CGS 16949A (free base) ; FAD286
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dexfadrostat.html
Concentration
10mM
Purity
98.75
Solubility
DMSO : 110 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C([C@H]2CCCC3=CN=CN23)C=C1
Molecular Formula
C14H13N3
Molecular Weight
223.27
Precautions
H315, H319, H320
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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