Thymine

Thymine, one of the four bases of DNA, is a substrate for rat liver dihydropyrimidine dehydrogenase (DPD), with a Km value of 2.2 μM, Ki of 24 μM (using 5-FU as the DPD substrate), and a specific activity of 0.68 nmol/min/mg[1].

Product Specifications

CAS Number

[65-71-4]

UNSPSC

12352005

Hazard Statement

H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/5-Methylpyrimidine-2,4_1H,3H_-dione.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic)

Smiles

O=C1NC(C(C)=CN1)=O

Molecular Formula

C5H6N2O2

Molecular Weight

126.11

Precautions

H319

References & Citations

[1]Tuchman M, et al. Effects of uridine and thymidine on the degradation of 5-fluorouracil, uracil, and thymine by rat liver dihydropyrimidine dehydrogenase. Cancer Res. 1985 Nov;45 (11 Pt 1) :5553-6.