(+) -Eudesmin

Pinoresinol dimethyl ether ((+) -Eudesmin) is a non-phenolic furanoid lignin. Pinoresinol dimethyl ether can be isolated from Magnolia biondii. Pinoresinol dimethyl ether activates MAPK, PKC, and PKA upstream pathways and inhibits NO levels. Pinoresinol dimethyl ether has neuroprotective activity[1][2][3].

Product Specifications

CAS Number

[29106-36-3]

Product Name Alternative

(+) -Eudesmine

UNSPSC

12352005

Hazard Statement

H302

Target

NO Synthase; p38 MAPK; PKA; PKC

Type

Natural Products

Related Pathways

Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pinoresinol-dimethyl-ether.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

COC1=CC=C([C@H]2OC[C@]3([H])[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@]32[H])C=C1OC

Molecular Formula

C22H26O6

Molecular Weight

386.44

Precautions

H302

References & Citations

[1]TeruhisaMiyauchi, et al. Formation of (+) -eudesmin in Magnolia kobus DC. Var. borealis sarg. Phytochemistry, 1998, 47 (4) : 665-670.|[2]Yang YJ, et al. Effects of (+) -eudesmin from the stem bark of magnolia kobus DC. var. borealis Sarg. on neurite outgrowth in PC12 cells. Arch Pharm Res. 2006 Dec;29 (12) :1114-8.|[3]Demiryürek AN, et al. Protective effects of verbenalin and (+) -eudesmin against 6-hydroxydopamine-induced oxidative/nitrosative stress in SH-SY5Y cells. Mol Biol Rep. 2023 Jan;50 (1) :331-338.