Vismodegib
Vismodegib (GDC-0449) is an orally active hedgehog pathway inhibitor with an IC50 of 3 nM. Vismodegib also inhibits P-gp, ABCG2 with IC50 values of 3.0 μM and 1.4 μM, respectively[1][2].
Product Specifications
CAS Number
[879085-55-9]
Product Name Alternative
GDC-0449
UNSPSC
12352005
Hazard Statement
H361
Target
Autophagy; Hedgehog
Type
Reference compound
Related Pathways
Autophagy; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Vismodegib.html
Purity
99.97
Solubility
DMSO : 50 mg/mL (ultrasonic) |Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1Cl)S(=O)(C)=O)NC2=CC=C(C(C3=NC=CC=C3)=C2)Cl
Molecular Formula
C19H14Cl2N2O3S
Molecular Weight
421.30
Precautions
H361
References & Citations
2+
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
Curated Selection
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