Clomipramine
Product Specifications
UNSPSC Description
Clomipramine (Chlorimipramine) is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
Target Antigen
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/clomipramine.html
Purity
99.48
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(C)CCCN1C2=CC(Cl)=CC=C2CCC3=CC=CC=C31
Molecular Weight
314.86
References & Citations
[1]Yumi Sugimoto, et al. The tricyclic antidepressant Clomipramine increases plasma glucose levels of mice. J Pharmacol Sci. 2003 Sep;93(1):74-9.|[2]Mushtaq Ahmed, et al. Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in <i>Bungarus sindanus</i> (krait) venom, human serum and rat striatum. J Enzyme Inhib Med Chem. 2008 Dec;23(6):912-7.|[3]Federica Cavaliere,The tricyclic antidepressant Clomipramine inhibits neuronal autophagic flux. Sci Rep. 2019 Mar 19;9(1):4881.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-B0457A/Clomipramine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-B0457A/Clomipramine-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
303-49-1
Available Sizes
Curated Selection
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