C5 Lenalidomide

C5 Lenalidomide (Lenalidomide 5'-amine) (Compound 8a) is a thalidomide analog and is a potent inhibitor of TNF-α production (IC50 = 100 μM in LPS stimulated human PBMC and IC50 = 480 nM in whole blood) [1].

Product Specifications

CAS Number

[191732-70-4]

Product Name Alternative

Lenalidomide 5'-amine

UNSPSC

12352005

Hazard Statement

H361, H373

Target

TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/c5-lenalidomide.html

Purity

99.62

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(C(N(CC1=C2C=CC(N)=C1)C2=O)CC3)NC3=O

Molecular Formula

C13H13N3O3

Molecular Weight

259.26

Precautions

H361, H373

References & Citations

[1]G W Muller, et al. Amino-substituted thalidomide analogs: potent inhibitors of TNF-alpha production. Bioorg Med Chem Lett. 1999 Jun 7;9 (11) :1625-30.