Eicosapentaenoic Acid

Eicosapentaenoic Acid (EPA) is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA) . Eicosapentaenoic Acid exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ) . Eicosapentaenoic Acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

Product Specifications

CAS Number

[10417-94-4]

Product Name Alternative

EPA; Timnodonic acid

UNSPSC

12352211

Hazard Statement

H227, H314, H318

Target

Endogenous Metabolite; Histone Demethylase

Type

Natural Products

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Eicosapentaenoic-Acid.html

Purity

99.86

Solubility

DMSO : ≥ 30 mg/mL

Smiles

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H30O2

Molecular Weight

302.45

Precautions

H227, H314, H318

References & Citations

[1]Martins, J.G., EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials. J Am Coll Nutr, 2009. 28 (5) : p. 525-42.|[2]Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.|[3]Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118 (43) :e2104689118.