Spirohypertone B

Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559) [1].

Product Specifications

UNSPSC

12352005

Target

TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/spirohypertone-b.html

Smiles

O=C1C(C(C2=CC=CC=C2)=O)=C(C)[C@@H](C/C=C(C)/C)C[C@]13C([C@@](C(OC4(C)C)=O)(C/C=C(C)\C)[C@@]4([H])C3)=O

Molecular Formula

C32H38O5

Molecular Weight

502.64

References & Citations

[1]Duan Y, et al. Spirohypertones A and B as potent antipsoriatics: Tumor necrosis factor-α inhibitors with unprecedented chemical architectures. Acta Pharm Sin B. 2024 Jun;14 (6) :2646-2656.