MPEG-Mal (MW 5000)

MPEG-Mal (MW 5000) (mPEG-Maleimide (MW 5000) ) is a PEG derivative and a thiol-specific chemical modification reagent. mPEG-Mal (MW 5000) can react with free cysteines in proteins, increasing the apparent molecular weight of the modified protein by 10-15 kDa to facilitate detection . mPEG-Mal (MW 5000) can also be used in research related to drug delivery to improve the stability and activity of drugs[1][2].

Product Specifications

CAS Number

[724722-89-8]

Product Name Alternative

MPEG-Maleimide (MW 5000)

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/methoxypolyethylene-glycol-maleimide.html

Purity

99.91

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COCCOCCNC(CCN1C(C=CC1=O)=O)=O.[n]

Molecular Weight

5000 (Average)

Precautions

H302, H315, H319, H335

References & Citations

[1]Pan LQ, et al. Site-specific PEGylation of a mutated-cysteine residue and its effect on tumor necrosis factor (TNF) -related apoptosis-inducing ligand (TRAIL) . Biomaterials. 2013 Dec;34 (36) :9115-23.|[2]Chen C, et al. Identification of a Disulfide Bridge in Sodium-Coupled Neutral Amino Acid Transporter 2 (SNAT2) by Chemical Modification. PLoS One. 2016 Jun 29;11 (6) :e0158319.