BD750

BD750, an effective immunosuppressant and a JAK3/STAT5 inhibitor, inhibits IL-2-induced JAK3/STAT5-dependent T cell proliferation, with IC50 values of 1.5 μM and 1.1 μM in mouse and human T cells, respectively[1][2].

Product Specifications

CAS Number

[892686-59-8]

UNSPSC

12352005

Hazard Statement

H301

Target

JAK; STAT

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bd750.html

Purity

99.02

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

OC1=C2CCCCC2=NN1C3=NC4=CC=CC=C4S3

Molecular Formula

C14H13N3OS

Molecular Weight

271.34

Precautions

H301

References & Citations

[1]Y Liu, et al. BD750, a benzothiazole derivative, inhibits T cell proliferation by affecting the JAK3/STAT5 signalling pathway. Br J Pharmacol. 2013 Feb;168 (3) :632-43.|[2]Yan Zhou, et al. Tolerogenic dendritic cells induced by BD750 ameliorate proinflammatory T cell responses and experimental autoimmune encephalitis in mice. Mol Med. 2017 Oct;23:204-214.