Loureirin B
Product Specifications
UNSPSC Description
Loureirin B, a flavonoid extracted from Dracaena cochinchinensis, is an inhibitor of plasminogen activator inhibitor-1 (PAI-1), with an IC50 of 26.10?μM; Loureirin B also inhibits KATP, the phosphorylation of ERK and JNK, and has anti-diabetic activity.
Target Antigen
ERK; JNK; PAI-1; Potassium Channel
Type
Natural Products
Related Pathways
MAPK/ERK Pathway;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Loureirin_B.html
Purity
99.16
Solubility
DMSO : ≥ 150 mg/mL
Smiles
O=C(C1=CC=C(O)C=C1)CCC2=C(OC)C=C(OC)C=C2OC
Molecular Weight
316.35
References & Citations
[1]Sha Y, et al. Loureirin B promotes insulin secretion through inhibition of KATP channel and influx of intracellular calcium. J Cell Biochem. 2017 Aug 17.|[2]He T, et al. Loureirin B Inhibits Hypertrophic Scar Formation via Inhibition of the TGF-β1-ERK/JNK Pathway. Cell Physiol Biochem. 2015;37(2):666-76.|[3]Bai X, et al. Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-β/Smad pathway. Exp Dermatol. 2015 May;24(5):355-60.|[4]Yu Jiang, et al. Bioactivity-Guided Fractionation of the Traditional Chinese Medicine Resina Draconis Reveals Loureirin B as a PAI-1 Inhibitor. Evidence-Based Complementary and Alternative Medicine
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N1504/Loureirin-B-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N1504/Loureirin-B-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
119425-90-0
Available Sizes
Curated Selection
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