Kukoamine B (mesylate)

Kukoamine B, a spermine alkaloid, is a potent dual LPS and CpG DNA inhibitor with Kd values of 1.23 µM and 0.66 µM, respectively. Kukoamine B exerts anti-inflammatory, anti-diabetic, anti-oxidant, anti-osteoporotic and neuroprotective effects. Kukoamine B has the potential for the study of sepsis. [1][2][3][4].

Product Specifications

CAS Number

[1375179-86-4]

UNSPSC

12352005

Target

Akt; Apoptosis; DNA/RNA Synthesis; MARK; MMP; PI3K; ROS Kinase

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/kukoamine-b-mesylate.html

Smiles

O=C(CCC1=CC=C(C(O)=C1)O)NCCCNCCCCN(CCCN)C(CCC2=CC=C(C(O)=C2)O)=O.O=S(O)(C)=O

Molecular Formula

C29H46N4O9S

Molecular Weight

626.76

References & Citations

[1]Li YY, et al. A Metabolomics Approach to Investigate Kukoamine B-A Potent Natural Product With Anti-diabetic Properties. Front Pharmacol. 2019 Jan 22;9:1575.