SARD279

SARD279 is a potent and selective Androgen Receptor degrader with DC50 value of 1099 nM. SARD279 can be used in prostate cancer research[1]. (Structure Note: Pink: target protein ligand (HY-117486) ; Blue, : Hyt (HY-W001578) ; Black: linker (HY-W004896) )

Product Specifications

CAS Number

[1489236-55-6]

UNSPSC

12352005

Target

Androgen Receptor; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/sard279.html

Purity

96.04

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(OCCOCCNC(CCCN(C1(C)C)C(N(C(C=C2)=CC(C(F)(F)F)=C2C#N)C1=O)=S)=O)CC3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3

Molecular Formula

C33H41F3N4O5S

Molecular Weight

662.76

References & Citations

[1]Salami J, et al. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun Biol. 2018 Aug 2;1:100.