SMI-4a
SMI-4a (TCS-PIM-1-4a) is a poten, selective, cell-permeable and ATP-competitive Pim-1 inhibitor with an IC50 of 24 μM and a Ki of 0.6 μM. SMI-4a also inhibits Pim-2 (IC50 of 100 μM), and does not significantly inhibit the other serine/threonine- or tyrosine-kinases. SMI-4a has anticancer activity[1].
Product Specifications
CAS Number
[438190-29-5]
Product Name Alternative
TCS-PIM-1-4a
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/_Z_-SMI-4a.html
Purity
99.85
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(NC/1=O)SC1=C/C2=CC=CC(C(F)(F)F)=C2
Molecular Formula
C11H6F3NO2S
Molecular Weight
273.23
Precautions
H302, H315, H319, H335
References & Citations
[1]Xia Z, et al. Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. J Med Chem. 2009 Jan 8;52 (1) :74-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1; PIM2
Available Sizes
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