Genistein-d4
Product Specifications
UNSPSC Description
Genistein-d4 is the deuterium labeled Genistein. Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis[1][2].
Target Antigen
Apoptosis; Autophagy; EGFR; Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis;Autophagy;JAK/STAT Signaling;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1C(C2=C(C([2H])=C(C([2H])=C2[2H])O)[2H])=COC3=CC(O)=CC(O)=C31
Molecular Weight
274.26
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Peterson G, et al. Genistein inhibits both estrogen and growth factor-stimulated proliferation of human breast cancer cells. Cell Growth Differ. 1996 Oct;7(10):1345-51.|[3]Ding S, et al. Environmentally Relevant Dose of Bisphenol A Does Not Affect Lipid Metabolism and Has No Synergetic or Antagonistic Effects on Genistein's Beneficial Roles on Lipid Metabolism. PLoS One. 2016 May 12;11(5):e0155352.
Shipping Conditions
Room Temperature
Clinical Information
No Development Reported
CAS Number
187960-08-3
Available Sizes
Curated Selection
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