PSB-0788

PSB-0788 is a new selective high-affinity A2B antagonist with IC50 value of 3.64 nM and Ki value of 0.393 nM, respeactively. PSB-0788 can be used for the research for chronic inflammatory lung diseases[1].

Product Specifications

CAS Number

[1027513-54-7]

UNSPSC

12352005

Target

Adenosine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/psb-0788.html

Purity

99.68

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C(N1CCC)=O)NC(C3=CC=C(S(=O)(N4CCN(CC4)CC5=CC=C(C=C5)Cl)=O)C=C3)=N2

Molecular Formula

C25H27ClN6O4S

Molecular Weight

543.04

References & Citations

[1]Thomas Borrmann, et al. 1-alkyl-8- (piperazine-1-sulfonyl) phenylxanthines: development and characterization of adenosine A2B receptor antagonists and a new radioligand with subnanomolar affinity and subtype specificity. J Med Chem. 2009 Jul 9;52 (13) :3994-4006.