HIE-124
HIE-124 is a potent ultra-short acting hypnotic that exhibits a rapid onset of action and a shorter duration of action with no acute tolerance or noticeable side effects. HIE-124 is promising for research of preanesthetic medication and anesthesia inducer[1].
Product Specifications
CAS Number
[805326-00-5]
UNSPSC
12352005
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hie-124.html
Smiles
O=C(C1=CSC(N1CCC2)=NC2=O)OCC
Molecular Formula
C10H12N2O3S
Molecular Weight
240.28
References & Citations
[1]El-Subbagh HI, et al. New ultra-short acting hypnotic: synthesis, biological evaluation, and metabolic profile of ethyl 8-oxo-5,6,7,8-tetrahydro-thiazolo[3,2-a][1,3]diazepin-3-carboxylate (HIE-124) . Bioorg Med Chem Lett. 2008 Jan 1;18 (1) :72-7. |[2]Taghizadeh M J, et al. Synthesis and docking study on thiadiazolo [3, 2-a][1, 3] diazepin-8 (5H) -one derivatives as selective GABA (A) agonists[J]. Journal of Pharmaceutical & Health Sciences, 2016, 4 (2) : 101-108.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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