CFTR corrector 15

CFTR corrector 15 (Compound 4172) is a corrector for cystic fibrosis transmembrane conductance regulator (CFTR), that repairs the F508del-CFTR folding defect when used with VX-809 (HY-13262) . CFTR corrector 15 can be used in research of cystic fibrosis disease[1].

Product Specifications

CAS Number

[1170387-92-4]

UNSPSC

12352005

Target

CFTR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/cftr-corrector-15.html

Purity

99.67

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC(NC(N2N=C(C=C2NC(C3(CCCC3)C4=CC=C(C=C4)Cl)=O)C5=CC=CS5)=N1)=O

Molecular Formula

C24H22ClN5O2S

Molecular Weight

479.98

References & Citations

[1]Vaccarin C, et al., Synthesis and Biological Evaluation of Pyrazole-Pyrimidones as a New Class of Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) . J Med Chem. 2024 Aug 22;67 (16) :13891-13908.