CHIR-99021 (Laduviglusib)

Product Specifications

CAS Number

252917-06-9

Synonyms

CT99021

SKU

C16218-10mM/1mL

Target

GSK-3

Applications

PI3K/Akt/mTOR

Smiles

CC1=CN=C (N1) C2=CN=C (N=C2C3=C (C=C (C=C3) Cl) Cl) NCCNC4=NC=C (C=C4) C#N

Molecular Formula

C22H18Cl2N8

Additionnal Information

Laduviglusib (CHIR-99021, CT99021) is a GSK-3α and GSK-3β inhibitor with IC50 of 10 nM and 6.7 nM, respectively. CHIR99201 does not exhibit cross-reactivity against cyclin-dependent kinases (CDKs) and shows a 350-fold selectivity toward GSK-3β compared to CDKs. CHIR99021 functions as a Wnt/β-catenin activator and induces autophagy.