Exarafenib

Product Specifications

CAS Number

2639957-39-2

Synonyms

KIN-002787, KIN-2787, RAF/KIN_2787

SKU

C01780-5mg

Target

Raf

Applications

MAPK

Additionnal Information

Exarafenib (KIN-002787, KIN-2787, RAF/KIN_2787) is an orally-available, selective inhibitor of pan-RAF. Exarafenib is effective in RAF-dependent cancers, including all classes of BRAF alterations. Exarafenib suppresses MAPK signaling in RAF-dependent melanoma cell lines. KIN-2787 exhibits low nanomolar to picomolar potency against RAF1, BRAF, and ARAF with an IC50 of 0.06-3.46 nM with minimal activity towards non-RAF kinases.