CWHM-1008
CWHM-1008 is a potent and orally active antimalarial agent, with EC50 values of 46 and 21 nM against agent-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively[1].
Product Specifications
CAS Number
[2362539-97-5]
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/CWHM-1008.html
Purity
99.06
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
C[C@H](NC([C@H]1CNC[C@@H]1C2=CC=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(C)C)C=C3
Molecular Formula
C22H26F3N3O
Molecular Weight
405.46
References & Citations
[1]Meyers MJ, et al. 4-Aryl Pyrrolidines as a Novel Class of Orally Efficacious Antimalarial Agents. Part 1: Evaluation of 4-Aryl- N-benzylpyrrolidine-3-carboxamides. J Med Chem. 2019 Mar 22.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Plasmodium
Available Sizes
Curated Selection
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