Chaetomellic acid A
Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of farnesyl-protein transferase. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice[1][2].
Product Specifications
CAS Number
[148796-51-4]
UNSPSC
12352211
Target
Farnesyl Transferase
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chaetomellic-acid-a.html
Smiles
O=C(O)/C(C)=C(CCCCCCCCCCCCCC)\C(O)=O
Molecular Formula
C19H34O4
Molecular Weight
326.47
References & Citations
[1]Nogueira A, et al. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. Biomed Res Int. 2017;2017:5125980.|[2]Lingham RB, et al. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase. Appl Microbiol Biotechnol. 1993 Nov;40 (2-3) :370-4.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Curated Selection
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