Chaetomellic acid A

Chaetomellic acid A can be isolated from Chaetomella acutiseta. Chaetomellic acid A is a specific inhibitor of farnesyl-protein transferase. Chaetomellic acid A decreases oxidative stress-induced apoptosis in cells. Chaetomellic acid A reduces renal damage after unilateral ureteral obstruction (UUO) in mice[1][2].

Product Specifications

CAS Number

[148796-51-4]

UNSPSC

12352211

Target

Farnesyl Transferase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/chaetomellic-acid-a.html

Smiles

O=C(O)/C(C)=C(CCCCCCCCCCCCCC)\C(O)=O

Molecular Formula

C19H34O4

Molecular Weight

326.47

References & Citations

[1]Nogueira A, et al. The Effects of Long-Term Chaetomellic Acid A Administration on Renal Function and Oxidative Stress in a Rat Model of Renal Mass Reduction. Biomed Res Int. 2017;2017:5125980.|[2]Lingham RB, et al. Chaetomella acutiseta produces chaetomellic acids A and B which are reversible inhibitors of farnesyl-protein transferase. Appl Microbiol Biotechnol. 1993 Nov;40 (2-3) :370-4.