M8-B
M8-B is a potent transient receptor potential melastatin-8 (TRPM8) antagonist. M8-B blocks cold-induced and TRPM8-agonist-induced activation TRPM8 channels. M8-B decreases deep body temperature (Tb) [1].
Product Specifications
CAS Number
[883976-12-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/m8-b.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC(C=C(CN(CCN)C(C1=CC=CS1)=O)C=C2)=C2OCC3=CC=CC=C3.Cl
Molecular Formula
C22H25ClN2O3S
Molecular Weight
432.96
Precautions
H302, H315, H319, H335
References & Citations
[1]Almeida MC, et al. Pharmacological blockade of the cold receptor TRPM8 attenuates autonomic and behavioral cold defenses and decreases deep body temperature. J Neurosci. 2012 Feb 8;32 (6) :2086-99.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TRPM8
Available Sizes
Curated Selection
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