Kokusaginine
Product Specifications
UNSPSC Description
Kokusaginine is a furoquinoline alkaloids, which exhibits inhibitory efficacy for acetylcholinesterase (AChE) with an IC50 of 28.2 μM. Kokusaginine exhibits anti-proliferative and apoptotic inducing effects in MCF-7/ADR cells[1][2].
Target Antigen
Apoptosis; Cholinesterase (ChE); Microtubule/Tubulin
Type
Natural Products
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton;Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kokusaginine.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2C(OC)=C3C(OC=C3)=NC2=C1)OC
Molecular Weight
259.26
References & Citations
[1]Sichaem J, et al., Furoquinoline Alkaloids from the Leaves of Evodia lepta as Potential Cholinesterase Inhibitors and their Molecular Docking. Nat Prod Commun. 2015 Aug;10(8):1359-62.|[2]Chen H, et al., The inhibitory effect of kokusaginine on the growth of human breast cancer cells and MDR-resistant cells is mediated by the inhibition of tubulin assembly. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2490-2492.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114803/Kokusaginine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114803/
Clinical Information
No Development Reported
CAS Number
484-08-2
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