VU0483605
VU0483605 is a potent and brain-penetrated mGlu1 receptor positive allosteric modulator (PAM) . VU0483605 shows excellent mGlu1 PAM activity at both human and rat, with EC50 values of 390 and 356 nM, respectively[1].
Product Specifications
CAS Number
[1623101-11-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/vu0483605.html
Purity
97.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=NC=CC=C1Cl)NC2=CC=C(N(C(C3=C4C=CC=C3Cl)=O)C4=O)C(Cl)=C2
Molecular Formula
C20H10Cl3N3O3
Molecular Weight
446.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Cho HP, Garcia-Barrantes PM, Brogan JT, et al. Chemical modulation of mutant mGlu1 receptors derived from deleterious GRM1 mutations found in schizophrenics. ACS Chem Biol. 2014;9 (10) :2334-2346.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1; mGluR4
Available Sizes
Curated Selection
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