AEP-IN-3
AEP-IN-3 (compound 18) is an orally active, potent and brain penetrant asparagine endopeptidase (AEP) inhibitor, with an IC50 of 7.8 ± 0.9 nM. AEP-IN-3 can be used for Alzheimer’s Disease (AD) research[1].
Product Specifications
CAS Number
[2978521-26-3]
UNSPSC
12352005
Target
Cathepsin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/aep-in-3.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1C[C@H](F)C[C@H]1C(N[C@@H](CC(N)=O)C#C)=O)C2(CC2)C3=CC=C(OC(F)(F)F)C=C3
Molecular Formula
C21H21F4N3O4
Molecular Weight
455.40
References & Citations
[1]Krummenacher D, et al. Discovery of Orally Available and Brain Penetrant AEP Inhibitors. J Med Chem. 2023 Dec 28;66 (24) :17026-17043.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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