Pyrimethamine

Pyrimethamine (Pirimecidan) is a potent, orally active dihydrofolate reductase (DHFR) inhibitor. Pyrimethamine is an antimalarial agent. Pyrimethamine affects the nucleoprotein metabolism of malarial parasites by interference in the folic–folinic acid systems and affects cell division by inhibiting the conversion of dihydrofolate to tetrahydrofolate[1][2].

Product Specifications

CAS Number

[58-14-0]

Product Name Alternative

Pirimecidan; Pirimetamin; RP 4753

UNSPSC

12352005

Hazard Statement

H302

Target

Antifolate; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/pyrimethamine.html

Concentration

10mM

Purity

99.99

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1

Molecular Formula

C12H13ClN4

Molecular Weight

248.71

Precautions

H302

References & Citations

[1]Aikawa M, et, al. Studies on nuclear division of a malarial parasite under pyrimethamine treatment. J Cell Biol. 1968 Dec;39 (3) :749-54.|[2]Martins-Duarte ÉS, et, al. Toxoplasma gondii: the effect of fluconazole combined with sulfadiazine and pyrimethamine against acute toxoplasmosis in murine model. Exp Parasitol. 2013 Mar;133 (3) :294-9.