VU0155094
VU0155094 is a positive allosteric modulator with differential activity at the various group III mGluRs[1].
Product Specifications
CAS Number
[731006-86-3]
Product Name Alternative
ML397
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vu0155094.html
Concentration
10mM
Purity
98.14
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)C1=CC=C(N2C(C)=C(C(CSC3=CC=C(NC(C)=O)C=C3)=O)C=C2C)C=C1
Molecular Formula
C24H24N2O4S
Molecular Weight
436.52
Precautions
H315, H319, H320
References & Citations
[1]Jalan-Sakrikar N, et al. Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7. ACS Chem Neurosci. 2014 Dec 17;5 (12) :1221-37.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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