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PARP7-IN-22

Product Specifications

UNSPSC Description

PARP7-IN-22 (XLY-1) is a PARP7 inhibitor with an IC50 of 0.6 nM. PARP7-IN-22 (XLY-1) is orally active, enhances type I interferon signaling in vitro, restores type I interferon signaling, promotes T cell infiltration into tumor tissues, and significantly inhibits tumor growth. PARP7-IN-22 shows promise for research in the field of cancer immunotherapy[1].

Target Antigen

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage;Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/parp7-in-22.html

Smiles

O=C1NN=CC(NCCCCNC(N2CCN(CC2)C3=NC=C(C=N3)C(F)(F)F)=O)=C1C(F)(F)F

Molecular Weight

508.42

References & Citations

[1]Yang J, et al. Discovery of highly potent PARP7 inhibitors for cancer immunotherapy[J]. Bioorganic Chemistry, 2024, 148: 107469.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-163719/PARP7-IN-22-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-163719/

Clinical Information

No Development Reported

Curated Selection

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