Duocarmycin SA

Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].

Product Specifications

CAS Number

[130288-24-3]

UNSPSC

12352203

Hazard Statement

H302, H340, H350, H360

Target

ADC Payload; Antibiotic; Apoptosis; DNA Alkylator/Crosslinker; Necroptosis

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/duocarmycin-sa.html

Purity

99.89

Solubility

DMSO : 50 mg/mL

Smiles

O=C(C(N1)=CC([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)OC

Molecular Formula

C25H23N3O7

Molecular Weight

477.47

Precautions

H302, H340, H350, H360

References & Citations

[1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6962-5.|[2]Boyle KE, et.al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28 (16) :2688-2692. |[3]Ichimura M, et.al. Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp. J Antibiot (Tokyo) . 1990 Aug;43 (8) :1037-8.