ATH686

ATH686 is a potent, selective and ATP-competitive FLT3 inhibitor. ATH686 target mutant FLT3 protein kinase activity and inhibit the proliferation of cells harboring FLT3 mutants via induction of apoptosis and cell cycle inhibition. ATH686 has antileukemic effects[1].

Product Specifications

CAS Number

[853299-52-2]

UNSPSC

12352005

Target

Apoptosis; FLT3

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ath686.html

Concentration

10mM

Purity

99.54

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

NC1=NC(OC2=CC=C(NC(NC3=CC(C(F)(F)F)=C(CN4CCN(CC)CC4)C=C3)=O)C=C2)=CC=N1

Molecular Formula

C25H28F3N7O2

Molecular Weight

515.53

References & Citations

[1]Ellen Weisberg, et al. Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison. Genes Cancer. 2010 Oct;1 (10) :1021-32.