Pyroxamide

Pyroxamide is a potent inhibitor of histone deacetylase 1 (HDAC1) with an ID50 of 100 nM. Pyroxamide can induce apoptosis and cell cycle arrest in leukemia[1].

Product Specifications

CAS Number

[382180-17-8]

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; HDAC

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pyroxamide.html

Purity

99.54

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NO)CCCCCCC(NC1=CC=CN=C1)=O

Molecular Formula

C13H19N3O3

Molecular Weight

265.31

Precautions

H302

References & Citations

[1]Butler LM, et al. Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7 (4) :962-70.|[2]Kutko MC, et al. Histone deacetylase inhibitors induce growth suppression and cell death in human rhabdomyosarcoma in vitro.Clin Cancer Res. 2003 Nov 15;9 (15) :5749-55.