Propafenone

Propafenone (SA-79), a sodium-channel blocker, acts an antiarrhythmic agent. Propafenone also has high affinity for the β receptor (IC50=32 nM) [1]. Propafenone blocks the transient outward current (Ito) and the sustained delayed rectifier K current (Isus) with IC50 values of 4.9 μm and 8.6 μm, respectively[2]. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction and induce apoptosis[3].

Product Specifications

CAS Number

[54063-53-5]

Product Name Alternative

SA-79

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor; Potassium Channel; Sodium Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/propafenone.html

Purity

99.64

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1OCC(O)CNCCC)CCC2=CC=CC=C2

Molecular Formula

C21H27NO3

Molecular Weight

341.44

Precautions

H302

References & Citations

[1]J T Lee, et al. The role of genetically determined polymorphic drug metabolism in the beta-blockade produced by propafenone. N Engl J Med. 1990 Jun 21;322 (25) :1764-8.|[2]A Seki, et al. Effects of propafenone on K currents in human atrial myocytes. Br J Pharmacol. 1999 Mar;126 (5) :1153-62.|[3]Wei-Bin Zheng, et al. Propafenone suppresses esophageal cancer proliferation through inducing mitochondrial dysfunction. Am J Cancer Res. 2017 Nov 1;7 (11) :2245-2256.