SPH3127
SPH3127 (DRI 18) is a novel, highly potent, and orally active direct renin inhibitor (recombinant human-renin IC50=0.4 nM, human plasma renin activity IC50=0.45 nM) . SPH3127 shows antihypertensive effect and can be used in essential hypertension research[1].
Product Specifications
CAS Number
[1399849-02-5]
UNSPSC
12352005
Target
Renin
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/sph3127.html
Concentration
10mM
Purity
98.26
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC)NCCCN1N=C([C@H](N(C2CC2)C([C@H]3CNCCO3)=O)C)C4=CC=C(C)N=C41
Molecular Formula
C22H32N6O4
Molecular Weight
444.53
References & Citations
[1]Daisuke Iijima, et al. Discovery of SPH3127: A Novel, Highly Potent, and Orally Active Direct Renin Inhibitor. J Med Chem. 2022 Aug 8.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
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