Stepharine
Stepharine, an natural alkaloid, directly interactes with TLR4 and binds to the TLR4/MD2 complex (TLR4 inhibitor) . Stepharine possesses anti-aging, anti-viral and anti-hypertensive effects[1].
Product Specifications
CAS Number
[2810-21-1]
UNSPSC
12352005
Target
Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/stepharine.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
COC1=C2C3(C=CC(C=C3)=O)C[C@]4([H])C2=C(CCN4)C=C1OC
Molecular Formula
C18H19NO3
Molecular Weight
297.35
References & Citations
[1]Tingyu Hao, et al. Inflammatory mechanism of cerebral ischemia-reperfusion injury with treatment of stepharine in rats. Phytomedicine. 2020 Dec;79:153353.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TLR4
Curated Selection
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