TPA-dT

TPA-dT is a thymidine analog with a tris[ (2-pyridyl) methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu (I) [1].

Product Specifications

UNSPSC

12352005

Target

Small Interfering RNA (siRNA)

Type

Reference compound

Related Pathways

Epigenetics

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tpa-dt.html

Solubility

10 mM in DMSO

Smiles

O[C@H]1C[C@H](N2C(N=C(OCC3=CC=CC(CN(CC4=NC=CC=C4)CC5=NC=CC=C5)=N3)C(C)=C2)=O)O[C@@H]1CO

Molecular Formula

C29H32N6O5

Molecular Weight

544.60

References & Citations

[1]Morihiro K, et al. Copper-mediated siRNA activation for conditional control of gene expression. Bioorg Med Chem Lett. 2024 May 15;104:129738.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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