TPA-dT
TPA-dT is a thymidine analog with a tris[ (2-pyridyl) methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu (I) [1].
Product Specifications
UNSPSC
12352005
Target
Small Interfering RNA (siRNA)
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tpa-dt.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C[C@H](N2C(N=C(OCC3=CC=CC(CN(CC4=NC=CC=C4)CC5=NC=CC=C5)=N3)C(C)=C2)=O)O[C@@H]1CO
Molecular Formula
C29H32N6O5
Molecular Weight
544.60
References & Citations
[1]Morihiro K, et al. Copper-mediated siRNA activation for conditional control of gene expression. Bioorg Med Chem Lett. 2024 May 15;104:129738.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GenTegra-DNA 0.5ml Screw Cap Tube, 100-Pack, supplied 4-envelopes of 25 tubes ea.
![Mouse Monoclonal Actin (Muscle Specific) Antibody (rMSA/953) [Alexa Fluor 647]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
Mouse Monoclonal Actin (Muscle Specific) Antibody (rMSA/953) [Alexa Fluor 647]
