TPA-dT
TPA-dT is a thymidine analog with a tris[ (2-pyridyl) methyl]amine (TPA) group. TPA-dT can be used to modify siRNAs. The TPA-modified siRNAs remain functionally inactive and is incapable of silencing gene expression until the TPA moiety is removed upon exposure to Cu (I) [1].
Product Specifications
UNSPSC
12352005
Target
Small Interfering RNA (siRNA)
Type
Reference compound
Related Pathways
Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tpa-dt.html
Solubility
10 mM in DMSO
Smiles
O[C@H]1C[C@H](N2C(N=C(OCC3=CC=CC(CN(CC4=NC=CC=C4)CC5=NC=CC=C5)=N3)C(C)=C2)=O)O[C@@H]1CO
Molecular Formula
C29H32N6O5
Molecular Weight
544.60
References & Citations
[1]Morihiro K, et al. Copper-mediated siRNA activation for conditional control of gene expression. Bioorg Med Chem Lett. 2024 May 15;104:129738.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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