Dapsone hydroxylamine

Dapsone hydroxylamine (DDS-NOH) induces methemoglobinemia. Dapsone hydroxylamine inhibits catalase (CAT) activity and reactive oxygen species generation. Dapsone hydroxylamine also has anti-inflammatory activity[1].

Product Specifications

CAS Number

[32695-27-5]

Product Name Alternative

DDS-NOH

UNSPSC

12352005

Hazard Statement

H302+H312

Target

Drug Metabolite; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/dapsone-hydroxylamine.html

Purity

94.92

Solubility

10 mM in DMSO

Smiles

O=S(C1=CC=C(C=C1)N)(C2=CC=C(C=C2)NO)=O

Molecular Formula

C12H12N2O3S

Molecular Weight

264.30

Precautions

H302+H312

References & Citations

[1]Albuquerque RV, et al. In Vitro Protective Effect and Antioxidant Mechanism of Resveratrol Induced by Dapsone Hydroxylamine in Human Cells. PLoS One. 2015 Aug 18;10 (8) :e0134768.|[2]Wozel G, et al. Dapsone hydroxylamine inhibits the LTB4-induced chemotaxis of polymorphonuclear leukocytes into human skin: results of a pilot study. Inflamm Res. 1997 Oct;46 (10) :420-2.