Kaempferol

Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].

Product Specifications

CAS Number

[520-18-3]

Product Name Alternative

Kempferol; Robigenin

UNSPSC

12352005

Hazard Statement

H301, H341

Target

Apoptosis; Autophagy; Endogenous Metabolite; Estrogen Receptor/ERR; HIV; Mitophagy; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Kaempferol.html

Purity

99.92

Solubility

DMSO : 20 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(OC(C3=CC=C(O)C=C3)=C(O)C2=O)=CC(O)=C1

Molecular Formula

C15H10O6

Molecular Weight

286.24

Precautions

H301, H341

References & Citations

[1]Luo H, et al. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine. 2012; 7: 3951-3959.|[2]Luo H, et al. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 September 15; 128 (2) : 513-519.|[3]An M, et al. Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48 (4) :235-43.|[4]Shin D, et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16 (12) :29980-95.