Cryptochlorogenic acid

Cryptochlorogenic acid (4-Caffeoylquinic acid) is a naturally occurring phenolic acid compound with oral effectiveness, anti-inflammatory, antioxidant and anti-cardiac hypertrophy effects. Alleviating LPS (HY-D1056) and ISO (HY-B0468) by regulating proinflammatory factor expression, inhibiting NF-κB activity, promoting Nrf2 nuclear transfer, and regulating PI3Kα/Akt/ mTOR / HIF-1α signaling pathway Induced physiological stress response[1][2][3].

Product Specifications

CAS Number

[905-99-7]

Product Name Alternative

4-Caffeoylquinic acid; 4-O-Caffeoylquinic acid

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; HIF/HIF Prolyl-Hydroxylase; Keap1-Nrf2; mTOR; NF-κB

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Cryptochlorogenic-acid.html

Purity

99.87

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(/C=C/C1=CC(O)=C(O)C=C1)O[C@@H]([C@@H]2O)[C@@H](C[C@](C(O)=O)(O)C2)O

Molecular Formula

C16H18O9

Molecular Weight

354.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang Jing, ea al.Simultaneous determination of chlorogenic acid, cryptochlorogenic acid, caffeic acid, naringin, hesperidin and linarin in Xiao′erjinning oral liquid by an HPLC method. China Journal of Chinese Materia Medica, 2010-13|[2]Zhao XL, et al. Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2020;83:106436.|[3]Li J, et al. Cryptochlorogenic acid and its metabolites ameliorate myocardial hypertrophy through a HIF1α-related pathway. Food Funct. 2022;13 (4) :2269-2282. Published 2022 Feb 21.