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AZD2906

AZD2906 is a selective glucocorticoid receptor (GR) agonist, increases micronucleated immature erythrocytes in the bone marrow of rats. AZD2906 shows IC50s of 2.2, 0.3, 41.6 and 7.5 nM at GR in human, rat PBMC and human, rat whole blood, respectively[1].

Product Specifications

CAS Number

[1034148-15-6]

UNSPSC

12352005

Target

Glucocorticoid Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/AZD2906.html

Purity

99.90

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FC1=CC=C(N2N=CC3=CC(O[C@@H]([C@@H](NC(C4CC4)=O)C)C5=CC=C(N=C5)OC)=CC=C23)C=C1

Molecular Formula

C26H25FN4O3

Molecular Weight

460.50

References & Citations

[1]Hayes JE, et al. Micronucleus induction in the bone marrow of rats by pharmacological mechanisms. I: glucocorticoid receptor agonism. Mutagenesis. 2013 Mar;28 (2) :227-32.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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