SARS-CoV-2 Papain-like Protease

<strong>SARS-CoV-2 Papain-like Protease</strong>_x000D_ <strong>Catalog number:</strong> B2017053_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 36.8 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> 2019-nCoV Plpro, COVID-19-Plpro, SARS-CoV-2 Plpro, Severe Acute Respiratory Syndrome Coronavirus 2 Papain-like Protease_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Ullrich S, Nitsche C. SARS-CoV-2 Papain-Like_Protease: Structure, Function and Inhibition Chembiochem. 2022 Oct 6;23(19):e202200327._x000D_ 2: Ton AT, Pandey M, Smith JR, Ban F, Fernandez M, Cherkasov A. Targeting SARS-CoV-2 papain-like_protease in the postvaccine era Trends Pharmacol Sci. 2022 Nov;43(11):906-919._x000D_ 3: Jiang H, Yang P, Zhang J. Potential Inhibitors Targeting Papain-Like_Protease of SARS-CoV-2: Two Birds With One Stone Front Chem. 2022 Feb 23;10:822785._x000D_ 4: Liu G, Lee JH, Parker ZM, Acharya D, Chiang JJ, van Gent M, Riedl W, Davis-Gardner ME, Wies E, Chiang C, Gack MU. ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2_papain-like_protease to evade host innate immunity Nat Microbiol. 2021 Apr;6(4):467-478._x000D_ 5: Cao D, Duan L, Huang B, Xiong Y, Zhang G, Huang H. The SARS-CoV-2 papain-like_protease suppresses type I interferon responses by deubiquitinating STING Sci Signal. 2023 May 2;16(783):eadd0082._x000D_ 6: Gao X, Qin B, Chen P, Zhu K, Hou P, Wojdyla JA, Wang M, Cui S. Crystal structure of SARS-CoV-2 papain-like_protease Acta Pharm Sin B. 2021 Jan;11(1):237-245._x000D_ 7: Stasiulewicz A, Maksymiuk AW, Nguyen ML, Bełza B, Sulkowska JI. SARS-CoV-2_Papain-Like_Protease Potential Inhibitors-In Silico Quantitative Assessment Int J Mol Sci. 2021 Apr 12;22(8):3957._x000D_ 8: Tan H, Hu Y, Jadhav P, Tan B, Wang J. Progress and Challenges in Targeting the SARS-CoV-2_Papain-like_Protease J Med Chem. 2022 Jun 9;65(11):7561-7580._x000D_ 9: Valipour M. Chalcone-amide, a privileged backbone for the design and development of selective SARS-CoV/SARS-CoV-2 papain-like protease inhibitors Eur J Med Chem. 2022 Oct 5;240:114572._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/36726755">10: Zang Y, Su M, Wang Q, Cheng X, Zhang W, Zhao Y, Chen T, Jiang Y, Shen Q, Du J, Tan Q, Wang P, Gao L, Jin Z, Zhang M, Li C, Zhu Y, Feng B, Tang B, Xie H, Wang MW, Zheng M, Pan X, Yang H, Xu Y, Wu B, Zhang L, Rao Z, Yang X, Jiang H, Xiao G, Zhao Q, Li J. High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors Protein Cell. 2022 Sep 28;14(1):17-27. </a>_x000D_ _x000D_ <strong>Products Related to SARS-CoV-2 Papain-like Protease can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>