DJ4

DJ4 is a ATP-competitive inhibitor of ROCK1/2 (IC50 values:5 and 50 nM) and MRCKα/β (IC50 values:10 and 100 nM) . DJ4 blocks stress fiber formation and inhibits migration and invasion of cancer cells. DJ4 can be used for study of lung cancer, breast cancer, and pancreatic (PANC-1) cancer[1].

Product Specifications

CAS Number

[1681020-24-5]

UNSPSC

12352005

Target

Cdc42-binding kinase; ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dj4.html

Purity

99.25

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N/C(S/C1=C/C2=CNC3=C2C=CC=N3)=N\CCC4=CC=CC=C4

Molecular Formula

C19H16N4OS

Molecular Weight

348.42

References & Citations

[1]Kale VP, et al. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett. 2014;354 (2) :299-310.