Hepcidin-1 (mouse) (TFA)

Hepcidin-1 (mouse) TFA is an endogenous peptide hormone involved in the regulation of iron homeostasis. Hepcidin-1 (mouse) TFA upregulates mRNA levels of TRAP, cathepsin K, and MMP-9 and increases TRAP-5b protein secretion. Hepcidin-1 (mouse) TFA downregulates the level of FPN1 protein and increases intracellular iron. Hepcidin-1 (mouse) TFA facilitates osteoclast differentiation[1].

Product Specifications

UNSPSC

12352209

Target

Cathepsin; Hepcidin; MMP

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hepcidin-1-mouse-tfa.html

Purity

98.04

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OC(C[C@H](N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC1=CC=CC=C1)C(N2[C@@H](CCC2)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]3C(N[C@@](C(N[C@H](C(N[C@]4([H])C(N[C@]5([H])C(N[C@H](C(N[C@]6([H])C(N[C@](CSSC6)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@](C(NCC(N[C@@](C(N[C@](CSSC4)([H])C(N[C@@H](CSSC3)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)([H])CSSC5)=O)CCC(N)=O)=O)CO)=O)CC(N)=O)=O)CC(N)=O)=O)=O)=O)CCCCN)=O)=O)=O)CC7=CC=CC=C7)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O.[x]

Molecular Formula

C111H169N31O35S8.xC2HF3O2

Molecular Weight

2754.24 (free base)

References & Citations

[1]Zhao GY, et al. Effects of mouse hepcidin 1 treatment on osteoclast differentiation and intracellular iron concentration. Inflammation. 2015 Apr;38 (2) :718-27.